Mucocutaneous manifestation of HIV and the correlation with CD4 count and viral load: A prospective study from Turkey HIV’in mukokutanöz bulguları ve CD4 sayısı ile viral yük arasındaki korelasyon: Türkiye’den prospektif bir çalışma
Turkiye Klinikleri Dermatoloji, cilt.30, sa.3, ss.88-94, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.5336/dermato.2020-79035
- Dergi Adı: Turkiye Klinikleri Dermatoloji
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, CAB Abstracts, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.88-94
- Anahtar Kelimeler: CD4- cell count, HIV, Mucocutaneous manifestation, Viral load
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: From the first reported cases in the early 1980s, Human Immunodeficiency Virus (HIV) infection has been a major global health concern. Although currently the infection is considered to consolidate in areas of severe social and economic distress, recent data on the epidemiology of HIV reveals that more than 36 million people live with HIV globally. HIV has a wide range of mucocutaneous manifestations, some of which are hallmark presentations of the infection. The aim of the present study is investigate the mucocutaneous manifestations in HIV-positive patients and their relationship with CD4-cell count and viral load. Material and Methods: A total of 105 consecutive HIV-positive patients (94 men, 11 women) were prospectively enrolled. Detailed information about patients’ demographic and clinical characteristics such as medical history, physical examination, laboratory evaluation, CD4- cell count and HIV RNA levels were recorded. Chi-square, Mann Whitney-U and Kruskal-Wallis tests were used for statistical analysis, with a significance threshold of p<0.05. Results: At least one mucocutanoues manifestation was detected in 82.9% of the patients. The most common mucocutanoues disorders were oral candidiasis (29%), xerosis cutis (23%), tinea pedis (18%), onychomycosis (14%) and seborrheic dermatitis (13%). Other sexually transmitted diseases were seen in 24.8% of the patients. There were not significant associations between the gender, CD4-cell count, HIV RNA copy count, treatment status and presence of mucocutaneous manifestations (p=0.454, p=0.543, p=0.850, p=0.125, respectively). On the other hand, the mean age and duration of HIV infection was significantly higher in patients with at least one mucocutaneous manifestation (p<0.05). Conclusion: This is the first prospective study from Turkey to address the mucocutaneous manifestations in HIV-infected patients. In our study, we found that the majority of patients with HIV infection had at least one mucocutaneous manifestation, the most common of which was oral candidiasis. Although further studies are needed to validate our assumption, our findings suggest that mucocutaneous manifestations might be indicators of HIV infection in our country.