Fine-needle aspiration cytology’s role in the diagnosis of salivary gland masses according to Milan classification

İNAN H. C., Yazıcı H., Ağırgöl B., Alpay M., Özer M., Özgen H.

Acta Oto-Laryngologica, cilt.146, sa.3, ss.320-325, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146 Sayı: 3
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1080/00016489.2025.2596866
  • Dergi Adı: Acta Oto-Laryngologica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Psychology & Behavioral Sciences Collection (EBSCO)
  • Sayfa Sayıları: ss.320-325
  • Anahtar Kelimeler: Salivary gland, parotid, submandibular, fine-needle aspiration, milan classification
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: Fine-needle aspiration cytology (FNAC) is extensively employed in the assessment of neoplastic pathology involving the parotid and submandibular glands. Aims/objectives: This study assessed the diagnostic value of FNAC in salivary gland tumors using the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Materials and methods: 152 patients who underwent surgery for parotid or submandibular gland tumors were included. FNAC results were compared with final histopathology. The risk of malignancy (ROM) and risk of neoplasia (RON) were investigated in all categories. Results: FNAC showed a sensitivity of 93.3%, specificity of 95.2%, positive predictive value of 70%, negative predictive value of 99.2%, and overall accuracy of 95% for detecting malignancy. Pleomorphic adenoma was the most common benign tumor, while salivary duct carcinoma was the most common malignancy. The risk of malignancy in the Milan categories V and VI was 100%. When the diagnostic value of FNAC in the detection of neoplasia was examined, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 92.7%, 62.5%, 95.0%, 52.6%, and 89.3%, respectively. Conclusions and significance: MSRSGC offers a standardized and effective approach for distinguishing benign from malignant salivary gland tumors.