Prophylactic usage of intracameral cefuroxime in the prevention of postoperative endophthalmitis
International Journal of Ophthalmology, cilt.9, sa.8, ss.1439-1443, 2009 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 8
- Basım Tarihi: 2009
- Doi Numarası: 10.3969/j.issn.1672-5123.2009.08.003
- Dergi Adı: International Journal of Ophthalmology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1439-1443
- Anahtar Kelimeler: Cefuroxime, Endophthalmitis, Intracameral injection, Phacoemulsification
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
• AIM: To evaluate the prophylactic usage of intracameral cefuroxime in the prevention of postoperative endophthalmitis (PE). • METHODS: Phacoemulsification surgery of 6 099 patients with age-related cataract was studied. retrospectively. In control group, 3 075 patients (3 075 eyes) had undergone surgery without use of intraocular antibiotics (IOA) between October 2001 and May 2004; and in study group 3 024 patients (3 024 eyes) had undergone the surgery with intracameral cefuroxime 1 mg in 0.1 mL between June 2004 and April 2007. Peroperative prophylaxis and operative procedures were the same in both groups. • RESULTS: PE developed in 13 (0.42%) and 4 (0.13%) patients in the control and the study groups respectively [P=0.031; odds ratio = 3.20 (1.04-9.84)]. PE developed 30 (3-75) days, and 25 (2-35) days after the surgeries in the two groups ( P = 0. 35) respectively. Monomicrobial infections were observed. In the study group Aspergillus fumigatus and Pseudomonas aeruginosa were resistant to cefuroxime; however, Streptococcus pneumonia was sensitive to cefuroxime. No sign of toxicity or allergy from intracameral cefuroxime was noted. • CONCLUSION: Intracameral prophylactic cefuroxime appears safe. It may provide considerable protection against bacterial PE; however, possibility of insufficient antibiotic coverage and antibiotic resistance of causative microorganism should be considered.