The Predictive Value of Early β-hCG Levels After Embryo Transfer in In Vitro Fertilization Treatment
Nigerian Journal of Clinical Practice, cilt.29, sa.1, ss.66-71, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.4103/njcp.njcp_124_25
- Dergi Adı: Nigerian Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.66-71
- Anahtar Kelimeler: beta-hCG, embryo transfer, in vitro fertilization, live birth
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Early serum beta-human chorionic gonadotropin (β-hCG) levels are commonly used to assess pregnancy viability following in vitro fertilization (IVF). However, their predictive value for live birth remains uncertain. Aim: This study evaluates the predictive value of early β-hCG levels on post-transfer days 12 and 14 in determining live birth outcomes after IVF. Methods: A retrospective chart review was conducted on 755 women who underwent IVF between 2017 and 2023. Demographic, clinical, and laboratory data were collected. Serum β-hCG levels were measured on post-transfer days 12 and 14. Receiver operating characteristic (ROC) curve analysis determined optimal β-hCG cutoff values for predicting live birth. Results: Among participants, 414 (54.8%) achieved live birth. Mean β-hCG levels on day 12 were significantly higher in the live birth group (554.5 ± 378.4 mIU/mL) compared to the non-live birth group (208.0 ± 162.5 mIU/mL, P < 0.001). On day 14, levels remained elevated in live birth cases (1466.8 ± 890.3 mIU/mL vs. 570.0 ± 452.8 mIU/mL, P < 0.001). The rate of β-hCG increase was also greater in the live birth group (P < 0.001). ROC analysis identified cutoffs of 205.5 mIU/mL on day 12 (72.4% sensitivity, 72.3% specificity) and 535 mIU/mL on day 14 (71.4% sensitivity, 71.3% specificity). Conclusion: Early β-hCG levels are strong predictors of live birth following IVF. Establishing clinical thresholds may enhance early pregnancy assessment and patient counseling.