HER 2 expression in gastric cancer Mide kanserinde HER 2 ekspresyonu
Journal of Clinical and Analytical Medicine, cilt.4, sa.4, 2013 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 4
- Basım Tarihi: 2013
- Doi Numarası: 10.4328/jcam.1038
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Anahtar Kelimeler: Gastric Cancer, HER 2, Immunohistochemstry
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: Even though gastric cancer incidence decline in many countries, it is still among the mostly witnessed cancers in the world. Gastric cancer is a biologically heterogeneous disease with many genetic and epigenetic variations. Despite this heterogeneity of the illness, patients in same stages received similar treatments. This changes as transtuzumab shows survival advantages in patients with metastatic gastric cancer. Therefore it is important to know the rate of HER 2 expression in patients with gastric cancer. In this study, we examined the rate of HER 2 expression in patients with gastric cancer by immunohistochemical method. Material and Method: A total of 50 patients with gastric adenocarcinoma who underwent diagnosed at Antalya Education and Research Hospital from 2008 to 2011 were enrolled in this study. Results: HER 2 expression of the 50 gastric carcinoma in tissue samples, 25 (50%) were scored as 0, 11 (22%) as 1, 7 (14%) as 2, and 7 (14%) as 3. The positive rate was approximately 14% (7/50). The HER-2 status was not correlated with the TNM stage, lymph node status, distant metastasis and age (p:0.344, p:0.315, p:0.181, p:0.96). The HER-2 status was correlated with sex (p:0.041). All of the HER-2 positive patients were male. Discussion: In our study only IHC method was performed and patients who had a score of 2+ were considered to have negative HER 2 expression. It is known that some of the patients with breast cancer with a score of 2+ established HER 2 expression by FISH method. Therefore, we think that HER 2 expression ratio may differ from the values we have obtained.