The relationship of soluble urokinase plasminogen activator receptor levels with preterm premature rupture of membranes and predictive value in neonatal intensive care unit admission
Revista da Associacao Medica Brasileira, cilt.72, sa.2, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 72 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1590/1806-9282.20251351
- Dergi Adı: Revista da Associacao Medica Brasileira
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Inflammation, urokinase plasminogen activator, Pregnancy, Preterm premature rupture of the membranes, Receptors
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: Preterm premature rupture of membranes is a pregnancy complication in which infection and inflammation play an important role. Soluble urokinase plasminogen activator receptor has been described as a biomarker of infectious and inflammatory diseases. The aim of this study was to evaluate maternal serum soluble urokinase plasminogen activator receptor levels in pregnant women with preterm premature rupture of membranes and to determine the predictive value in neonatal outcomes. METHODS: In this prospective case-control study, complete blood count parameters, serum C-reactive protein, and soluble urokinase plasminogen activator receptor levels of 40 pregnant women with preterm premature rupture of membranes and 40 randomly selected healthy pregnant women between 22 and 34 weeks’ gestation were recorded. Neutrophil-to-lymphocyte ratio, systemic inflammation response index, and systemic immune-inflammation index were calculated. Receiver operating characteristic analysis assessed the predictive value of maternal serum soluble urokinase plasminogen activator receptor levels for neonatal intensive care unit admission. RESULTS: Maternal serum soluble urokinase plasminogen activator receptor levels, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and systemic inflammation response index scores were significantly higher in the preterm premature rupture of membranes group than in controls (p<0.05). The soluble urokinase plasminogen activator receptor value in receiver operating characteristic analysis identified 4.33 ng/mL (62% sensitivity, 64% specificity) and 3.65 ng/mL (72% sensitivity, 73% specificity) for neonatal intensive care unit admission and adverse perinatal outcomes in the preterm premature rupture of membranes group (p<0.05). CONCLUSION: Soluble urokinase plasminogen activator receptor may be used as an ancillary marker in the prediction of neonatal intensive care unit admission and adverse perinatal outcome in preterm premature rupture of membranes cases, along with clinical findings.