Diastolic function abnormalities in active rheumatoid arthritis evaluation by conventional Doppler and tissue Doppler: Relation with duration of disease
Clinical Rheumatology, cilt.25, sa.3, ss.294-299, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 3
- Basım Tarihi: 2006
- Doi Numarası: 10.1007/s10067-005-0014-3
- Dergi Adı: Clinical Rheumatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.294-299
- Anahtar Kelimeler: diastolic function, rheumatoid arthritis, tissue Doppler imaging
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The aim of this study was to evaluate left ventricular diastolic function in patients with active rheumatoid arthritis (RA), analyzing conventional Doppler and tissue Doppler echocardiographic imaging (TDI) which is a new echocardiographic application, with special regard to disease duration. Methods: Fifty-two patients with active RA and 47 healthy persons were included in this study. Duration of disease ranged from 3 to 324 months (mean 76±85 months). All patients and the control group were evaluated by M-mod, two-dimensional, conventional Doppler echocardiography and TDI. Results: Among conventional Doppler transvalvular mitral flow parameters, late diastolic flow velocity (A) and deceleration time (DT) values were higher in patients with RA than that in the control group (p<0.001). E (early diastolic flow velocity)/A ratio was found to be lower in patients with RA than that in the control group (p<0.001). Mitral annular early diastolic velocity (Em), among TDI parameters, was found to be lower in patients with RA than that in the control group (p<0.001). Em/Am (mitral annular late diastolic velocity) ratio was found to be lower in RA patients compared with that in the control group (p<0.001). The relation was found between A (r=0.43, p=0.001), DT (r=0.30, p=0.03), E/A ratio (r=0.40, p=0.004), Em (r=0.32, p=0.02), Em/ Am ratio (r=0.30, p=0.03), and E/Em (r=0.32, p=0.02), with disease duration in patients with RA. Conclusion: At present, it is concluded that active RA patients, in the absence of clinical evidence of heart disease, show diastolic dysfunction characterized by impaired E/A ratio, Em/ Am ratio, and DT. The relation between diastolic dysfunction and disease duration suggests a subclinical myocardial involvement. © Clinical Rheumatology 2006.