Proton magnetic resonance spectroscopy findings in the left temporal lobe of patients with schizophrenia Şizofreni olgularında sol temporal lob proton manyetik rezonans spektroskopi bulguları
Gulhane Medical Journal, cilt.51, sa.3, ss.152-157, 2009 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 3
- Basım Tarihi: 2009
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.152-157
- Anahtar Kelimeler: Left temporal lobe, Proton magnetic resonance spectroscopy, Schizophrenia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Most of the symptoms of schizophrenia bring mind the symptoms of temporal area illnesses. 1H-MRS studies carried out on schizophrenia patients focused especially on temporal and frontal lobes and basal ganglions. In this study, it was aimed to detect the 1H-MRS findings of left temporal lobe in patients with Schizophrenia. Twenty seven patients diagnosed to have schizophrenia according to the criteria of DSM-IV and 10 healthy control cases were included in the study. The symptoms of schizophrenia were assessed with the Brief Psychiatric Rating Scale, The Assessment of Positive Symptoms Scale and The Assessment of Negative Symptoms Scale. All the spectroscopic images were collected with the same MRI device. Patients with schizophrenia had a higher level of creatine and a lower level of N-acetyl aspartate/creatine ratio when compared to the control group. Other metabolite levels in the study group were similar to those of the control group. In addition, there was no significant correlation between the metabolite levels and clinical characteristics and scale ratios. The findings in this study indicate a hipometabolic state and loss of neurons due to the depletion of N-acetyl aspartate/creatine levels in the left temporal lobes of the Schizophrenia patients. Our results support those who advocate the theory that Schizophrenia is a neurodevelopmental disorder. © Gülhane Askeri Ti{dotless}p Akademisi 2009.