External validation of a new nomogram for prediction of cancer specific and all-cause mortality in bladder cancer patients undergoing radical cystectomy
Kuwait Medical Journal, cilt.53, sa.3, ss.306-311, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 3
- Basım Tarihi: 2021
- Dergi Adı: Kuwait Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.306-311
- Anahtar Kelimeler: bladder cancer, cancer specific survival, nomogram, overall survival
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To externally validate a new nomogram (Williams SB, Huo J, Chu Y, et al. Mortality in bladder cancer patients undergoing radical cystectomy: Development and validation of a nomogram for treatment decision-making. Urology 2017; 110:76-83) in our patient cohort Design: Retrospective study Setting: Department of Urology, Health Sciences University, Bozyaka Training and Research Hospital, Izmir, Turkey Subjects: A total of 146 patients who were diagnosed with muscle invasive bladder cancer between March 2006 and October 2016 were enrolled in this study. Interventions: Radical cystectomy Main outcome measures: The predicted cancer specific survival (CSS) and overall survival (OS) by the recent nomogram were compared with the actual CSS and OS of the patients in our single center sample. Results: Mean overall survival of the patients was 54.5±4.4 months; the 3-year and 5-year OS rates were found to be 46.2% and 42.3%. Mean CSS of the patients was 66.5±4.8 months and 3-year and 5-year CSS rates were found to be 59.2% and 53%. Three-year and 5-year OS and CSS results according to the nomogram were found as 54.8% (±12.6), 38.6% (±10.8) and 75.3% (±11.6), 62.8% (±12), respectively. Statistically significant difference was found between the actual values and nomogram results for 3-year and 5-year OS and CSS rates. Conclusion: The recent nomogram failed to estimate both OS and CSS in our group of patients that have more likely underwent cystectomy and have relatively homogenous age distribution.