Risk of Hypercalcemia in the Elderly Patients with Hypervitaminosis D and Vitamin D Intoxication
Clinical Laboratory, cilt.69, sa.3, ss.523-529, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.7754/clin.lab.2022.220518
- Dergi Adı: Clinical Laboratory
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.523-529
- Anahtar Kelimeler: complication, elderly, hypercalcemia, hypervitaminosis D, intoxication
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: We aimed to evaluate the risk of hypercalcemia in the elderly population with hypervitaminosis D and vitamin D intoxication. Methods: A total of 121 patients with a 25(OH) vitamin D level > 100 ng/mL from patients aged ≥ 65 years who ap-plied to our hospital between 2014 and 2020 were included in this study. Sixty-nine patients with 25(OH) vitamin D levels of 100 - 150 ng/mL were determined as D hypervitaminosis; 52 patients with 25(OH) vitamin D levels > 150 ng/mL were determined as vitamin D intoxication. People with a calcium level above 10.2 mg/dL were consid-ered as hypercalcemic patients. Results: Of 121 patients with D hypervitaminosis and vitamin D intoxication, 103 (85.1%) were normocalcemic, and 18 (14.9%) were hypercalcemic. Hypercalcemia was detected in 9 out of 69 patients with hypervitaminosis D; 8 of them had mild hypercalcemia and 1 person had severe hypercalcemia. Hypercalcemia was detected in 9 of 52 patients with vitamin D intoxication; mild hypercalcemia was found in 7 people, moderate hypercalcemia in 1 per-son, severe hypercalcemia in 1 person. There was no statistically significant difference between the incidence of hypercalcemia in patients with D hypervitaminosis and vitamin D intoxication (p = 0.514). It was observed that a total of 3 (16.7%) of the hypercalcemic patients with D hypervitaminosis and vitamin D intoxication died. Conclusions: In the elderly population with hypervitaminosis D and vitamin D intoxication, most of the patients were seen as normocalcemic. However, severe hypercalcemia, which was life-threatening and resulted in death, was also observed. Using vitamin D in elderly patients should be performed according to the guideline recommen-dations. Calcium level and clinical findings should be checked during follow-up.