Sinonasal Cancers: Single Center Experience
Indian Journal of Otolaryngology and Head and Neck Surgery, cilt.77, sa.8, ss.2759-2765, 2025 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 77 Sayı: 8
- Basım Tarihi: 2025
- Doi Numarası: 10.1007/s12070-025-05531-3
- Dergi Adı: Indian Journal of Otolaryngology and Head and Neck Surgery
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.2759-2765
- Anahtar Kelimeler: Maxillary sinus carcinoma, Diplopia, Induction chemotherapy, Nasal carcinoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
To share our experience of sinonasal cancer management as a tertiary center.This is a retrospective study from a single tertiary center. The staging was performed according to the AJCC, 8th edition.A total of twenty-six patients were included in the study. The majority of the patients were male (76.9%), with the maxillary sinus as the primary tumor being predominant (80.8%), as was squamous cell histology (65.5%). T4 tumors at diagnosis accounted for 61.5% of the patients. The local recurrence rate was 23.1%. Induction chemotherapy was the initial treatment choice for 11.5% (n = 3) of the patients. Primary surgery was selected for 7.7% of the patients, and chemoradiotherapy was the treatment choice for 53.8%. The median follow-up duration was 56 months (95%CI: 29.8–82.1). The median overall survival (OS) was not reached, with 61.5% of patients remaining alive. The median disease-free survival (DFS) was not reached. Additionally, 61.5% of patients did not experience local recurrence or metastasis. Local recurrence was identified as an adverse prognostic factor for OS (NR vs 30 months, 95%CI 0.543–59.457, p = 0.037). Intracranial extension was identified as an adverse prognostic factor for DFS (NR vs. 7 months, 95%CI 0–14.321, p = 0.019).SNCs are rare and heterogeneous cancers that require a multidisciplinary management approach. Due to nonspecific symptoms, most patients are diagnosed at advanced stages. More prospective data are needed to optimize patient care.