The importance of serum CXCL-16 levels in patients with grade III-V Chronic Kidney Disease
Turkish Nephrology, Dialysis and Transplantation Journal, cilt.23, sa.3, ss.234-239, 2014 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 3
- Basım Tarihi: 2014
- Doi Numarası: 10.5262/tndt.2014.1003.10
- Dergi Adı: Turkish Nephrology, Dialysis and Transplantation Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.234-239
- Anahtar Kelimeler: Chronic kidney disease, Chemokine ligand-16, Glomerular filtration rate, Endothelial dysfunction, Cardiovascular diseases
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: A number of studies report CXCL-16 as a new chemokine that mediates the collection of leukocytes and adhesion of macrophages to coronary artery smooth muscle cells, and stimulates atherosclerosis. However, there is a limited number of studies evaluating the levels of CXCL-16 in patients with Chronic Kidney Disease (CKD). We aimed to determine the serum level of CXCL-16 in patients with CKD and to clarify the relationship between CXCL-16 and hsCRP and glomerular filtration. MATERIAL and METHODS: Two hundred and twenty two patients with CKD were included in the study. The patients were divided into 3 groups according to the glomerular filtration rate (GFR) in accordance with the K/DOQI guideline. Patients with primary glomerulonephritis or tubulointerstitial nephritis, heart failure, or hepatic disease, patients who used immunosuppressive or cytotoxic drugs and renin-angiotensin system blockers were excluded from the study. RESULTS: There was a positive correlation between the grade of renal failure and CXCL-16 levels and a negative correlation between the GFR and CXCL-16 levels ( p<0.001).There was a positive correlation between CXCL-16 and hsCRP ( p <0.001). Decreased GFR, increased PTH and hsCRP levels, and the presence of DM and HT were associated with serum CXCL-16 elevation on multiple regression analysis. CONCLUSION: The results indicated that decreased GFR levels were associated with increased hsCRP and CXCL-16 levels in chronic kidney disease.