Evaluation of Myeloperoxidase/Paraoxonase-1 Ratio and Dysfunctional HDL Levels in Ankylosing Spondylitis and Their Relationship With Coronary Artery Disease
International Journal of Clinical Practice, cilt.2026, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2026 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1155/ijcp/2520813
- Dergi Adı: International Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: To determine the level of dysfunctional high-density lipoprotein (dHDL) with the myeloperoxidase/paraoxonase-1 (MPO/PON-1) ratio and its relationship with epicardial adipose tissue thickness (EATT) in patients with ankylosing spondylitis (AS). Methods: Total cholesterol, triglyceride, HDL, low-density lipoprotein, MPO, and PON-1 levels of 50 AS patients and 50 healthy volunteers were studied. The MPO/PON-1 ratio was calculated as the dHDL marker. EATT and ejection fraction of patients and the control group were measured by echocardiography. Results: There was no difference between the patient and control groups in terms of HDL, LDL, and triglyceride levels (p > 0.05 for all). A significant difference was detected between the two groups in terms of MPO, PON-1 levels, MPO/PON-1 ratio, and EATT (p < 0.05 for all). While there was a positive correlation between MPO level and MPO/PON-1 ratio and EATT, a negative correlation was found between PON-1 level and EATT (p < 0.05 for all). Conclusions: We found that the ratio of MPO/PON-1, which is considered a biochemical marker of coronary artery disease (CAD), is higher in AS patients. Additionally, we demonstrated a significant relationship between EATT and the MPO/PON-1 ratio. We showed the relationship with the ratio. We think that the MPO/PON-1 ratio and EATT may be associated with subclinical cardiovascular risk in patients with AS; however, their potential diagnostic utility requires further longitudinal studies specifically designed to evaluate predictive performance.