Comparison of switching treatment from ranibizumab to aflibercept and aflibercept to ranibizumab on serous pigment epithelial detachments due to age-related macular degeneration
Retina-Vitreus, cilt.33, sa.1, ss.39-50, 2024 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 1
- Basım Tarihi: 2024
- Doi Numarası: 10.37845/ret.vit.2024.33.7
- Dergi Adı: Retina-Vitreus
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.39-50
- Anahtar Kelimeler: Intraretinal fluid, Neovascular age-related macular degeneration, Pigment epithelial detachment, Subretinal fluid
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To evaluate the effects of switching between vascular endothelial growth factor inhibitors (anti-VEGF) treatments in patients with extensive serous pigment epithelial detachment (sPED) due to neovascular age-related macular degeneration (nAMD). Materials and Methods: This was a retrospective analysis of data where 38 patients (38 eyes) with fovea involving sPED of ≥200 μm measured manually using the caliper on the OCT due to AMD. The cases were divided into 2 groups. Group 1: included patients who were initially treated with intravitreal Ranibizumab (0.5 mg/0.05 ml) and then switched to intravitreal Aflibercept (2.0 mg/0.05ml). Group 2: included patients who were initially treated with intravitreal Aflibercept (2.0 mg/0.05ml) and then switched to intravitreal Ranibizumab (0.5 mg/0.05 ml). The outcome measures of best-corrected visual acuity (BCVA), PED height, PED width, the presence of subretinal fluid (SRF), intraretinal fluid (IRF), number of injections, and follow-up periods. Results: At baseline, all patients in Group 1 had SRF. At switch, Group 1:22(%100) eyes, Group 2:16(%100) eyes had SRF. After the switch last visit, Group 1:11(%50) eyes, Group 2:8(%50) eyes had SRF (p=1.00). At baseline, Group 1:13(%59) eyes, Group 2:5(%31) eyes had IRF. At switch, Group 1: 1(%4.5) eyes, Group 2:1(%6) eyes had IRF. After switching the last visit, Group 1:1(%4.5) eyes, Group 2:1(%6) eyes had IRF (p= 0.816). Conclusions: Our study found that both anti-VEGF switch treatments showed similar anatomical and functional effectiveness with a significant reduction in PED height and increases SRF, IRF absorption.