The role of leuko-glycemic index in predicting 30-day mortality in diabetic and non-diabetic patients with acute coronary syndrome
Hong Kong Journal of Emergency Medicine, cilt.33, sa.4, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/hkj2.70114
- Dergi Adı: Hong Kong Journal of Emergency Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: acute coronary syndrome, diabetic, leuko-glycemic index, mortality, non-diabetic
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: The leuko-glycemic index (LGI) has been suggested as a possible prognostic marker for Acute coronary syndrome (ACS) but, its predictive capacity for mortality, especially among individuals with diabetes, remains poorly understood. Objective: In this study, we aimed to evaluate the predictive capability of LGI concerning 30-day in-hospital mortality among emergency room patients, who were diagnosed with ACS and subsequently treated in the coronary intensive care unit (CICU). Methods: From 1 January 2022 to 1 January 2023, consecutive patients with ACS admitted to the CICU of a tertiary Emergency Department (ED) were enrolled. The cohort was stratified by diabetes status, and the prognostic performance of the admission LGI for 30-day in-hospital mortality was evaluated. Results: We enrolled 397 patients in the present investigation. Especially, deceased diabetic patients presented with significantly higher LGI values (p < 0.001). LGI showed that the area under the curve for predicting mortality was 0.674 in diabetic patients and 0.679 in non-diabetic patients. For diabetic patients, an LGI ≥ 2757.6 mg/dl.mm3 yielded a sensitivity of 61%, specificity of 77%, negative predictive value (NPV) of 90%, and positive predictive value (PPV) of 36%. In non-diabetic patients, an LGI value of ≥ 1783.4 mg/dl.mm3 yielded 47% sensitivity, 91% specificity, 95% NPV, and 31% PPV. Higher LGI independently predicted in-hospital mortality in diabetic patients (OR = 1.000, 95% CI [1.000–1.001], p = 0.009). Conclusions: Our results suggests that higher LGI values are independent predictors of 30-day mortality in diabetic patients. The inclusion of LGI in existing risk assessment methodologies within the ED setting has the potential to refine prognostic precision and guide therapeutic decision-making for individuals presenting with chest pain.