The efficacy of gabapentin in patients with failed back surgery: A prospective case series
Journal of Musculoskeletal Pain, cilt.13, sa.4, ss.27-32, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 4
- Basım Tarihi: 2005
- Doi Numarası: 10.1300/j094v13n04_06
- Dergi Adı: Journal of Musculoskeletal Pain
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.27-32
- Anahtar Kelimeler: failed back, gabapentin, low back pain, neuropathic pain, treatment
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Failed back surgery syndrome [FBSS] causes persistent low back problems in approximately 15 percent of patients who undergo spinal surgery for lumbar disc herniation. As reported by recent clinical data, gabapentin, an antiepileptic agent, is increasingly being used for chronic pain, with a favorable side effect profile. The aim of this study was to investigate the efficacy of gabapentin in patients with FBSS associated chronic back pain. Methods: Nine patients with chronic back pain diagnosed with FBSS according to clinical, lumbar spinal magnetic resonance imaging and electrodiagnostic findings were studied. Each patient received titrated dosage of gabapentin from 900 to 2400 mg/day. Pretreatment levels of pain and the degree of disability were measured using a visual analog scale and the Oswestry disability index. All nine patients were re-evaluated at six weeks and six months. Results: Eight of nine patients reported significant decrease in pain and disability scores at six weeks and six months after treatment. One patient who underwent spinal surgery five times did not report benefit from gabapentin. Gabapentin was well tolerated and there were no significant side effects. Conclusion: Our results indicate that gabapentin monotherapy may be an effective adjunct for the treatment of FBSS associated chronic low back pain. © 2005 by The Haworth Press, Inc. All rights reserved.