Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency
Wiener Klinische Wochenschrift, cilt.128, sa.21-22, ss.822-826, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 128 Sayı: 21-22
- Basım Tarihi: 2016
- Doi Numarası: 10.1007/s00508-015-0769-8
- Dergi Adı: Wiener Klinische Wochenschrift
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.822-826
- Anahtar Kelimeler: Killer-cell immunoglobulin-like receptor, Common variable immunodeficiency, Human leukocyte antigen-C alleles
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: We aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population. Methods: In all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing method was used in molecular genetic analysis. The frequencies of the genes in the study groups were statistically compared with each other using chi-square or Fisher exact tests, whichever were appropriate. Results: Although there was no significant difference between both study groups with respect to distribution of KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was significantly lower than that in healthy population (P = 0.008). Conclusion: This present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, may play a role in the pathogenesis of CVID.