Comparison of various simple insulin sensitivity and β-cell function indices in lean hyperandrogenemic and normoandrogenemic young hirsute women
Fertility and Sterility, cilt.80, sa.1, ss.133-142, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 80 Sayı: 1
- Basım Tarihi: 2003
- Doi Numarası: 10.1016/s0015-0282(03)00497-7
- Dergi Adı: Fertility and Sterility
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.133-142
- Anahtar Kelimeler: insulin resistance, beta-cell function, normoandrogenemia, hyperandrogenemia, hirsutism
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To assess and compare various simple insulin sensitivity and β-cell function indices in lean, hirsute, young women. Design: Prospective study. Setting: Departments of endocrinology and metabolism at a university and a state hospital. Patient(s): Seventy-one hirsute young women were classified as hyperandrogenemic or normoandrogenemic. Main Outcome Measure(s): Insulin sensitivity and β-cell function indices derived from a single sample and an oral glucose tolerance test (OGTT). Result(s): Lean hyperandrogenemic hirsute women have insulin resistance and increased β-cell function. The most sensitive indices of insulin resistance were total and 1-hour and 2-hour post-challenge insulin levels during OGTT. When a cut-off value of 3.2 or greater for homeostasis model assessment of insulin resistance (HOMA-IR) was accepted, 46% of hyperandrogenemic women and 30% of normoandrogenemic women were insulin resistant. Fasting insulin level was best correlated with the fasting insulin resistance index, HOMA-IR, and Quicky index. The HOMA-IR was best correlated with fasting insulin level and the hepatic insulin sensitivity index (ISIHOMA). Conclusion(s): Insulin levels based on OGTT are the most useful index of insulin resistance and β-cell function index in hirsute women. The HOMA-IR may be a proposed global test for insulin resistance; it correlated well with both OGTT-derived insulin resistance and β-cell function indices and with global insulin resistance indices derived from a single sample (such as ISI HOMA, Quicky index, FIRI-1, fasting Belfiore index, and glucose/insulin ratio). © 2003 by American Society for Reproductive Medicine.