ADC of Diffusion-weighted MRI and SUVmax of 18 F-FDG-PET/CT: Correlation with Prognostic Factors and Distant Metastasis in Breast Cancer

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Çifci K. E., Nazli M. A., Baykara Ulusan M., ARSLAN E.

Turk Onkoloji Dergisi, cilt.38, sa.2, ss.180-190, 2023 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.5505/tjo.2023.3473
  • Dergi Adı: Turk Onkoloji Dergisi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.180-190
  • Anahtar Kelimeler: Apperent diffusion coefficient, breast cancer, diffusion-weighted magnetic resonance imaging, positron emission tomography
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

OBJECTIVE We aimed to evaluate the relationship between apparent diffusion coefficient (ADC), maximum standardized uptake value (SUVmax ), and prognostic factors in breast cancer (BC) and to investigate the contribution of these parameters in determining the distant metastases at the time of diagnosis in BC. METHODS The study included 209 patients with invasive BC at the time of initial diagnosis. Patients under-went whole-body18 F-fluorodeoxyglocose positron emission tomography/computed tomography and breast magnetic resonance imaging including diffusion weighted imaging. Histologic grade (HG), histological type, human epidermal growth factor 2 (HER-2), Ki-67, estrogen receptor (ER), and progesterone receptor (PR) markers of the breast tumor were evaluated in pathological sam-ples. Tumor-node-metastasis (TNM) staging was performed based on clinical, pathological, and imaging findings. RESULTS HER-2 positivity and PR positivity demonstrated a strong correlation with distant metastasis (p=0.00040 ve 0.00045). ER positivity was positively correlated with SUVmax (p=0.0001) and SUVmax /ADCmean (p=0.006). PR was positively correlated with ADCmean (0.028). SUVmax was correlated with the tumor size (p=0.008), TNM stage (p=0.022 and r=0.159), and HG (p<0.0001 and r=0.347). CONCLUSION Both SUVmax and ADCmean are helpful parameters in determining prognosis in BC. HER-2 and PR positivity, and tumor size can be used as revealing and useful parameters in determining distant metastases.