The Association Between Hematological Indices and Prognosis in Crescentic Glomerulonephritis Asociación entre Índices Hematológicos y Pronóstico en Glomerulonefritis Semilunar
Revista de Nefrologia, Dialisis y Trasplante, cilt.46, sa.1, ss.3-11, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 1
- Basım Tarihi: 2026
- Dergi Adı: Revista de Nefrologia, Dialisis y Trasplante
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Fuente Academica Plus, EMBASE, Directory of Open Access Journals, DIALNET, Academic Search Ultimate (EBSCO)
- Sayfa Sayıları: ss.3-11
- Anahtar Kelimeler: crescentic glomerulonephritis, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, Systemic immune-inflammation index
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Crescentic glomerulonephritis (cGN) is a highly aggressive condition that can quickly progress to chronic kidney disease (CKD) or end-stage renal disease (ESRD). Due to the limited number of studies on this topic, this research aimed to investigate the relationship between the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) with the prognosis of crescentic glomerulonephritis. Methods: This observational retrospective study included 127 patients diagnosed with crescentic glomerulonephritis by renal biopsy. Among these cases, 1.6% (n=2) were classified as type 1 crescentic GN, 51.2% (n=65) as type 2, and 47.2% (n=60) as type 3. We analyzed baseline values for SII, NLR, and PLR, with SII calculated as (platelet count × neutrophil count) / lymphocyte count. We evaluated the association of these indicators, specifically a greater than 50% decrease in estimated glomerular filtration rate (eGFR), with the development of end-stage kidney failure (ESKD) and mortality. Results: When comparing groups based on changes in eGFR, we did not find a statistically significant difference in NLR, PLR, or SII. However, patients with ESKD exhibited significantly higher values of these indices compared to those without ESKD. Additionally, no association was observed between these indices and mortality. Conclusion: This study suggests that elevated SII, NLR, and PLR levels may indicate the severity of renal damage in patients with crescentic GN. Further research with larger patient populations is necessary to confirm these findings.