New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid
European Cytokine Network, cilt.22, sa.2, ss.118-122, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 2
- Basım Tarihi: 2011
- Doi Numarası: 10.1684/ecn.2011.0284
- Dergi Adı: European Cytokine Network
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.118-122
- Anahtar Kelimeler: valproate, apelin, visfatin, adiponectin, vaspin
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim. To investigate the relationship between the newly discovered adipocytokines and increasing body weight (paralleled by increased insulin resistance), and antiepileptic drug therapy with valproic acid (VPA). Design and methods. 44 children with idiopathic, generalized epilepsy treated with valproic acid (VPA), and 40 control group children were included in this study. Results. Both the VPA-treated group and the control group showedno significant difference in terms of age, total cholesterol and LDL-cholesterol. Subjects in theVPAgroup had significantly higher BMI-SDS than control subjects (2.3±0.15 vs -0.04±0.8, p<0.001). HOMA-IR, apelin and visfatin levels were significantly increased (4.95±2.07 vs 1.46 vs 0.6, p<0.001; 2.21±1.14 vs 0.57±0.15, p<0.001; 31±12 vs 18.4±10.4, p<0.001; respectively), and adiponectin levels were significantly lower in the VPA group (2.02±1.03 vs 12.4±6.1, p<0.001). Triglyceride levels were significantly increased (126±70 vs 80±40 mg/dL, p=0.001), and HDLcholesterol levels were significantly lower in the VPA group. Vaspin levels were higher in the VPA group than the control group, but the difference was not significant. Conclusion. Based on the findings of this study, apelin, visfatin and adiponectin levels may be considered as potential regulators of glucose and fat metabolism during valproic acid therapy.