Preoperative short-term radiochemotherapy in locally-advanced rectal cancer: Comparison of two different radiotherapy fractionation regimens Lokal i̇leri rektum kanserinde preoperatif kisa süreli radyokemoteraphi: İki farkli radyoterapi fraksiyonasyon şemasinin karşilaştirilmasi
Turkiye Klinikleri Journal of Medical Sciences, cilt.25, sa.1, ss.46-50, 2005 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 1
- Basım Tarihi: 2005
- Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.46-50
- Anahtar Kelimeler: Drug-therapy, Radiotherapy, Rectal neoplasms
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: In this study, the effects of differentiated preoperative short-term rectal radiochemotherapy on local pelvic failure, overall survival, treatment-related side effects and sphincter preservation are evaluated. Material and Methods: 32 rectal cancer patients underwent preoperative radiochemotherapy with concomitant 5-Flutouracil (5-FU) between 1995 and 1999. Patients were divided into two groups of varying fractionation. Group 1, with 18 patients, received a total of 20 Gy external radiotherapy in 4 consecutive days of 5 Gy/fraction and Group 2, with 14 patients, received a total external dose of 25 Gy during 5 consecutive days with 5 Gy/fraction. Both groups underwent surgery within 10 days after completion of radiotherapy. All patients received adjuvant 5-FU and calcium leucovorin chemotherapy postoperatively. Results: One patient died of ileus just after completion of radiochemotherapy and 1 succumbed to sepsis during the early postoperative period. Overall survival in the median 32 months follow-up (range 1-60 months) for groups 1 and 2 was 39% and 57%, respectively (p= 0.31). Local pelvic failure for groups 1 and 2 was 50% and 36%, respectively (p= 0.43). Varying the fractionation did not result in a statistically significant effect on treatment-related side effects and the frequency of sphincter-sparing surgery. Conclusion: Variations in preoperative radiochemotherapy fractionation regimens in locally advanced rectal carcinoma did not reveal significant differences in overall survival, local pelvic recurrence, morbidity/mortality and sphincter-sparing surgery. Copyright © 2005 by Türkiye Klinikleri.