Co-occurrence of Neuroleptic Malignant Syndrome and Silent Syndrome in a Patient With Bipolar Disorder: Clinical Challenges and Long-term Neurological Sequelae
Cerebellum, cilt.25, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s12311-026-01959-7
- Dergi Adı: Cerebellum
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Psycinfo, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: SILENT syndrome, Neuroleptic malignant syndrome, Lithium toxicity, Ataxia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
A 31-year-old male with bipolar disorder on long-term lithium therapy presented to our emergency department with cerebellar and extrapyramidal signs, accompanied by fever and elevated creatine kinase levels. Cerebellar symptoms persisted for one year during follow-up. The patient was diag- nosed with Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) and concomitant neuroleptic malignant syndrome (NMS). This case highlights the rare coexistence of these serious complications, underscores the diagnostic and therapeutic challenges, and contributes to the litera- ture on clinical management.