External radiotherapy in macular degeneration: Our technique, dosimetric calculation, and preliminary results
International Journal of Radiation Oncology Biology Physics, cilt.40, sa.4, ss.923-927, 1998 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 4
- Basım Tarihi: 1998
- Doi Numarası: 10.1016/s0360-3016(97)00859-6
- Dergi Adı: International Journal of Radiation Oncology Biology Physics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.923-927
- Anahtar Kelimeler: macular degeneration, radiotherapy, carcinogenesis risk
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: This study was performed to determine the toxicity and efficacy of external-beam radiotherapy in patients with age-related subfoveal neovascularization. Methods and Materials: Between January 1996 and September 1996, 25 patients with a mean age of 70.5 (60-84) years were enrolled. All patients underwent fluorescein angiographic evaluation and documentation of their neovascular disease prior to irradiation. A total of 25 patients were treated with a total dose of 12 Gy in 6 fractions over 8 days. We used a lens-sparing technique and patients were treated with a single lateral 6-MV photon beam. To assess the risk of radiation carcinogenesis after treatment of age-related subfoveal neovascularization, we estimated the effective dose for a standard patient on the basis of tissue-weighting factors as defined by the International Commission on Radiological Protection (ICRP). The calculations were made with TLD on a male randophantom. The lens dose was found to be 0.217 Gy per fraction. Results: No significant acute morbidity was noted. Visual acuity was maintained or improved in 76% and 80% of treated patients at their 1- and 3-month follow-up examinations, respectively. On angiographic imaging, there was stabilization of subfoveal neovascular membranes in 23 patients (92%) at 3 months after irradiation. Conclusion: Our observations on these 25 patients in this study indicate that many patients will have improved or stable vision after radiotherapy treatment with low- dose irradiation.