Evaluation of corneal and lens densitometry in children with familial Mediterranean fever
Photodiagnosis and Photodynamic Therapy, cilt.39, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.pdpdt.2022.102990
- Dergi Adı: Photodiagnosis and Photodynamic Therapy
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Corneal densitometry, Lens densitometry, Familial Mediterranean Fever, Scheimpflug camera
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: This study aimed to investigate the presence of subclinical inflammation in the eye by examining corneal and lens changes in children with familial Mediterranean fever (FMF) and provide the regulation for follow-up and treatment protocols according to the presence of signs of inflammation. Design: This is a cross-sectional, case-control study. Methods: Topographic parameters and corneal and lens densitometry of 48 patients with FMF (10.12 ± 3.84 years [range: 5–19 years]) and 33 healthy volunteers (10.94 ± 3.78 years [range: 5–19 years]; p > 0.05) were evaluated with a Scheimpflug camera. For corneal densitometric measurements, the cornea was divided into four concentric radial zones and anterior, central, and posterior layers according to corneal thickness. The mean densitometry value for the crystalline lens was calculated in three zones around the center of the pupil. Results: Corneal light backscattering in all layers and zones of the cornea were similar between the patient and control groups. Lens densitometry values in the three zones did not differ between the two groups (p > 0.05). Maximum lens densitometry values were found to be significantly higher in the patient group (22.14 vs 19.11; p = 0.011). Conclusion: Monitoring the cornea and lens density in patients with FMF using Pentacam may help to show the presence of subclinical inflammation and regulate the follow-up and treatment protocols. Larger sample sizes and prospective design studies are needed to reach more conclusive results.