Comparison of 68GA-FAPI-04 PET/CT and 18F-FDG PET/CT findings in peritonitis carcinomatosa cases
Hellenic Journal of Nuclear Medicine, cilt.26, sa.1, ss.26-34, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 1
- Basım Tarihi: 2023
- Dergi Adı: Hellenic Journal of Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.26-34
- Anahtar Kelimeler: drguzel@gmail.com
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: This study was conducted to compare the diagnostic accuracy of gallium-68-radiolabeled broblast activation protein inhibitor (68Ga-FAPI-04), positron emission tomography/computed tomography (PET/ CT), and uorine-18-uorodeoxyglucose (18F-FDG) PET/CT based on the peritoneal carcinomatosis (PC) index for detecting peritoneal metastases of various cancer types, and to evaluate the potential benets of FAPI PET/CT in patients with peritoneal metastases. Subjects and Methods: This retrospective study included 57 patients with peritoneal metastases between November 2020 and December 2021. All patients underwent 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT scans within 7 days. Results: Among the 57 patients included, 32 (56.1%) were male and the median age was 54 years (22-86 years). In the visual evaluation made from a total of 13 quadrants on the abdominopelvic peritoneal surfaces, positive ndings were observed in 111 quadrants in 39 patients by 18F-FDG PET/CT and in 280 quadrants in 57 patients by 68Ga-FAPI-04 PET/CT (P<0.001). The maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR) values of 68Ga-FAPI-04 PET/CT for the PC lesions were signicantly higher than the SUVmax and TBR values of 18F-FDG PET/CT in all patients and in all quadrants (SUVmax 6.45 vs 4.1; P<0.001; TBR 14.9 vs 6.8; P<0.001). Conclusion: Gallium-68-FAPI-04 PET/CT showed superior sensitivity compared to 18F-FDG PET/CT in both quantitative and visual evaluations of PC. Considering the low background activity and higher specic activity uptake values, 68Ga-FAPI-04 PET/CT helped improve diagnostic accuracy.