Can Systemic Inflammation Response Index (SIRI) and Neutrophil-to-lymphocyte Ratio (NLR) Predict the Presence of Placenta Accreta Spectrum in Pregnant Women with Placenta Previa? Sistemik Enflamasyon Yanıt İndeksi (SIRI) ve Nötrofil-lenfosit Oranı (NLR), Plasenta Previalı Gebe Kadınlarda Plasenta Akreta Spektrumunun Varlığını Öngörebilir mi?
Medical Journal of Bakirkoy, cilt.21, sa.1, ss.48-54, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/bmj.galenos.2025.2025.1-7
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.48-54
- Anahtar Kelimeler: Inflammatory biomarkers, placenta accreta spectrum, placenta previa, systemic inflammatory response index
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Can systemic inflammation response index (SIRI) and neutrophil-to-lymphocyte ratio (NLR) predict the presence of placenta accreta spectrum (PAS) in pregnant women with placenta previa (PP)? Methods: This retrospective case-control study included 415 singleton pregnancies diagnosed with PP, of which 119 were in the study group with PAS, and 296 were with no evidence of placental invasion. Demographic characteristics, laboratory parameters, and SIRI values of the groups were compared. Cut-off values that could predict PAS were calculated. Results: The mean gravidity, parity, abortion, and number of previous cesarean sections were higher in the PAS group compared to the control. Gestational age was lower in the PAS group. There was no significant difference between the groups regarding body mass index and maternal age. Mean lymphocyte and platelet counts were lower in the PAS group, while red cell distribution width (RDW) was higher than the control group. The cut-off value for RDW was 3.63 (66% sensitivity, 48% specificity) in the receiver operating characteristic (ROC) curve. The optimal sensitivity/specificity balance for NLR was 4.49, with 46% sensitivity and 69% specificity in the ROC curve. Conclusion: RDW and NLR are useful auxiliary indicators for predicting PAS. The increases in SIRI values in the PAS group were not statistically significant. The relationship between inflammatory parameters and the histological subtypes of PAS should be investigated in larger case groups.