The efficacy of trospium chloride in women with an overactive bladder
Marmara Medical Journal, cilt.21, sa.2, ss.127-132, 2008 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 2
- Basım Tarihi: 2008
- Dergi Adı: Marmara Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.127-132
- Anahtar Kelimeler: Overactive bladder, Voiding dysfunction, Pharmacotherapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The efficacy of trospium chloride on lower urinary tract symptoms and urodynamic parameters in women with OAB were investigated. Material and Methods: Forty-four consecutive women with OAB were enrolled in this study. Before and after 8 weeks of TC treatment, OAB-V8 scores of the patients related to the current symptoms were collected. Urodynamic studies were performed in 28 patients (63.6%). Primary and outcome variables were OAB symptom score and urodynamic findings. The difference in response to TC according to the lower urinary tract symptoms between the patients with or without proven detrusor overactivity was analyzed. Results: Mean OAB-V8 score of the patients after the treatment with TC was significantly lower than before the treatment (11.9±6.3; 24.9±±5.1; p<0.05). After treatment, when compared to the mean OAB-V8 score of patients without DO (14.2±5.3), the mean symptom score of those with proven DO (10.3±4.1) was found to be statistically lower (p<0.05). Conclusion: Trospium was much more effective in improving symptoms in women with proven DO than in women without DO.