Human leukocyte antigen class ii alleles and dental caries in a child population
Pediatric Dentistry, cilt.30, sa.2, ss.154-159, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 2
- Basım Tarihi: 2008
- Dergi Adı: Pediatric Dentistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.154-159
- Anahtar Kelimeler: HLA allele, caries, mutans streptococci
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Purpose: The purpose of this study was to investigate a possible relationship between human leukocyte antigens (HLAs) DRB1 and DQB1, dental caries, and colonization by mutans streptococci (MS) in children. Methods: Sixty children were clinically examined for caries in accordance with World Health Organization criteria and methods. Thereafter, subjects were assigned into 2 groups: (1) high-caries children (dft and DMFT ≥5); and (2) caries-free children (dft and DMFT=0). Fresh saliva samples were collected and tested for mutans streptococci, after which the subjects were placed into 2 groups, having either high (≥105 colony-forming units [CFU]/mL saliva) or low (<105 CFU/mL saliva) numbers of micro-organisms in saliva. The polymerase chain reaction/sequence specific primer method was used to determine HLA DNA typing from fresh blood samples. Results: There was no significant difference between the frequency of HLA alleles in high-caries and caries-free subjects. Although chi-square test suggested an association for HLA-DRB1 *01 and HLA-DQB1*03 with the salivary numbers of MS (P=.026 and P=.009, respectively), these could not be confirmed by logistic regression analysis (P=.188 and P=.101, respectively). Conclusions: The results obtained fail to establish an association between human leukocyte antigen alleles DRB1 and DQB1 and salivary numbers of MS in the selected child population.