Chronic necrotizing pulmonary aspergillosis in an elderly patient with acute myeloid leukemia-M2 in remission Remisyonda akut myeloid lösemi-M2'li yaşli bir hastada kronik nekrotizan pulmoner aspergillozis
Turk Geriatri Dergisi, cilt.15, sa.1, ss.98-101, 2012 (SCI-Expanded, SSCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 1
- Basım Tarihi: 2012
- Dergi Adı: Turk Geriatri Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.98-101
- Anahtar Kelimeler: Acute, Invasive pulmonary aspergillosis, Itraconazole, Leukemia, Myeloid, Thoracotomy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
This paper presents a case of chronic necrotizing pulmonary aspergillosis (CNPA) in a 61-yearold male patient with acute myeloid leukemia-M2 (AML-M2). The patient was admitted to our clinic with non-productive cough for eight months and hemoptysis for four months. He had been diagnosed with AML-M2 and treated with cytosine-arabinoside and idarubicin seven months earlier. Thorax computed tomography (CT) demonstrated bilateral, perivascular, and multiple small nodules as well as multiple thick wall cavitary lesions with irregular margins in the entire lung areas, especially the upper lobes. An open lung biopsy by thoracotomy was performed and mixed inflammatory cells, necrosis (without caseation), multinuclear giant cells, epitheloid histiocytes, and aspergillus hyphae with bronchial wall destruction were seen in biopsy specimens from the right upper lobe. The patient was treated with amphotericine B for three weeks. As a follow-up, itraconazole was administered for a year. The patient is the first case where CNPA along with an overt immune-compromising disease such as AML-M2 has been observed in one patient.