Relationship Between Uric Acid, Proteinuria, and Atherogenic Index of Plasma in Renal Transplant Patients
Transplantation Proceedings, cilt.50, sa.10, ss.3376-3380, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 10
- Basım Tarihi: 2018
- Doi Numarası: 10.1016/j.transproceed.2018.05.021
- Dergi Adı: Transplantation Proceedings
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.3376-3380
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
This study aimed to determine the association of atherogenic index of plasma (AIP) with both hyperuricemia and proteinuria in renal transplant recipients. Material and Methods: Between the years 2015 and 2017, 61 renal transplant recipients with at least 1 year of follow-up were included in this retrospective cohort study. Uric acid levels of ≥7 mg/dL in men and ≥6 mg/dL in women were accepted as hyperuricemia. The patients were separated into groups according to their serum uric acid and AIP levels. Results: The prevalence of patients with hyperuricemia was 37.7% (n = 23). The triglycerides (P =.009), AIP (P =.005), proteinuria (P =.04), and C-reactive protein (P =.049) were significantly higher in the hyperuricemic group compared with the nonhyperuricemic group. The levels of uric acid (P =.008) and proteinuria (P =.005) increased significantly with an elevation in AIP levels. Additionally, in multivariate linear regression analysis, uric acid (β = 0.325; P =.008) and estimated glomerular filtration rate (β = −0.291; P =.02) were found to be independently associated factors for proteinuria in renal transplant patients (R2 = 0.242; P <.001). Conclusion: We indicated that uric acid, AIP, and proteinuria are closely related. Further prospective studies are needed to evaluate the causal relationship between uric acid, AIP, and proteinuria in this patient group.