EVALUATION OF PLASMA ALPHA KLOTHO LEVELS IN OBESE CASES PROCENA NIVOA ALFA-KLOTO PROTEINA U PLAZMI KOD GOJAZNIH ISPITANIKA
Journal of Medical Biochemistry, cilt.45, sa.6, ss.1307-1315, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 6
- Basım Tarihi: 2026
- Doi Numarası: 10.5937/jomb0-60664
- Dergi Adı: Journal of Medical Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), East & Central Europe Database (ProQuest), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Materials Science & Engineering Collection (ProQuest), Pharma Collection (ProQuest), Technology Collection (ProQuest)
- Sayfa Sayıları: ss.1307-1315
- Anahtar Kelimeler: carotid intima media thickness, klotho, oxidative stress, obesity
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Klotho is an anti-ageing gene that extends lifespan when overexpressed and accelerates ageing when disrupted. In our study, we will investigate the correlations between plasma a-Klotho (a-KL) protein levels with body mass index (BMI), carotid intima media thickness (CIM T), total antioxidant status (TAS), total oxidant status (TO S), oxidative stress index (OSI), high-sensitivity C-reactive protein (hsCRP) and cholesterol values in obese patients. Methods: This study was conducted as a single-centre, cross-sectional study. Results: The study included 90 participants: 35 women (38.9% ) and 55 men (61.1% ). Of the participants included in the study, 30 were normal weight (33.3% ) (Group 1), 30 were overweight (33.3% ) (Group 2), and 30 were obese (33.3% ) (Group 3). There were statistically significant differences in the a-K L protein (p = 0 . 0 1 0 ), hsCRP (p < 0. 001), and homeostasis model assessment of insulin resistance (HOMA-IR) (p = 0 . 0 2 2 ) between the study groups. There is no significant difference between the study groups for CIM T (p = 0. 380), TOS (p = 0. 613), TAS (p = 0. 056), or OSI (p= 0.943). Conclusions: In this study, the overweight group had a-K L protein levels that were significantly higher than those in the obese group, whereas hsCRP levels were significantly higher in the obese group than in the overweight and normal weight groups. There were no significant differences in CIMT, TAS, TO S, and OSI values between the study groups. There were no significant correlations between a-KL protein values and BMI, hsCRP CIMT, TAS, TO S, or OSI in participants in the study.