INTERACTION OF APELIN, ELABELA AND NITRIC OXIDE IN SCHIZOPHRENIA PATIENTS INTERAKCIJA APELINA, ELABELA I AZOT OKSIDA KOD PACIJENATA KOJI BOLUJU OD ŠIZOFRENIJE

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ÇATAK Z., Kaya H., Kocdemir E., Ugur K., Guzel S. P., Yardim M., ...Daha Fazla

Journal of Medical Biochemistry, cilt.39, sa.2, ss.184-190, 2020 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2478/jomb-2019-0029
  • Dergi Adı: Journal of Medical Biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.184-190
  • Anahtar Kelimeler: schizophrenia, elabela, apelin, nitric oxide
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: Apelin (APLN), elabela (ELA), and nitric oxide (NO) have effects on physiological and behavioural properties in biological systems. This study was designed to determine APLN, ELA and NO levels in schizophrenia patients and assess whether these molecules are of diagnostic value. Methods: A total of 33 schizophrenic patients and 32 ageand sex-adjusted healthy participants were included in the study. ELA, APLN and NO levels were measured using ELISA methods. Results: Although the ELA and NO levels of the patients were lower than the control group, APLN levels were higher (p = 0.039, p = 0.019, p = 0.048, respectively). There was a significant negative correlation between APLN levels and triglyceride (TG) and body mass index (BMI) levels (r =-0.426, p = < 0.001 and r =-0.330, p = 0.007, respec tively). Respectively, the areas under the receiver-operating characteristic (ROC) curves of the ELA/APLN, ELA/NO and APLN/NO ratios were 0.628, 0.590 and 0.709, 95% confident intervals (CI): 0.491–0.764, 0.450–0.730 and 0.579–0.840. Conclusions: Decreased levels of ELA and NO and increased APLN levels in schizophrenia suggest that these molecules may be involved in its etiopathology. The APLN/NO ratio also seems to show promise in the diagnosis of the disease and may be used in future.