Analysis of effect of increased and reduced renal sympathetic nerve activity on arterial blood pressure by using a mathematical model Bobrek sempatik sinir aktivitesinde artma ve azalmanin atardamar kan basinci uzerine etkisinin matematik model kullanarak analizi

KARAASLAN F.

2021 Medical Technologies Congress, TIPTEKNO 2021, Antalya, Türkiye, 4 - 06 Kasım 2021, (Tam Metin Bildiri)

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1109/tiptekno53239.2021.9632977
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Anahtar Kelimeler: Kidney, Sodium, Mathematical Model
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Renal sympathetic nerves directly affect renin secretion, tubular sodium reabsorption, and renal vascular resistance. An increase in renal sympathetic nerve activity increases renin secretion, sodium reabsorption, and renal vascular resistance. On the other side, a decrease in renal sympathetic nerve activity decreases tubular sodium reabsorption, renin secretion, and renal vascular resistance. Simulations in this study are performed by using a mathematical model. Renal sympathetic nerve activity is raised from a normal to a high level (130% of normal), at which it is maintained for 10 days before it is dropped to a low level (70 % of normal), at which it is maintained for 10 days. During the elevation of renal sympathetic nerve activity, an increase in renin concentration, tubular sodium reabsorption and renal vascular resistance is observed. This leads to a decrease in renal sodium excretion, leading to a sustained increase in the extracellular fluid volume, blood volume and arterial blood pressure. During the reduction of renal sympathetic nerve activity compensatory mechanisms work in the opposite direction. These simulation results support the hypothesis that arterial blood pressure is increased to achieve sodium balance during an increase in renal sympathetic nerve activity.