Short term olfactory memory and olfactory function after inhalation anesthetic agents: a randomized clinical trial Memória olfativa de curta duração e função olfativa após anestésicos inalatórios: estudo clínico randomizado
Brazilian Journal of Anesthesiology, cilt.70, sa.1, ss.36-41, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 70 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.1016/j.bjan.2019.12.005
- Dergi Adı: Brazilian Journal of Anesthesiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.36-41
- Anahtar Kelimeler: Olfactory memory, Inhalation anesthesia, Desflurane, Sevoflurane
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background and objectives: This clinical trial aimed to evaluate the effects of two different inhalation anesthetic agents on postoperative olfactory memory and olfactory function in patients who underwent micro laryngeal surgery. Methods: This randomized prospective controlled study consisted of 102 consecutive patients with a voice disorder. The patients underwent micro laryngeal surgery for voice disorders under general anesthesia. Patients who did not meet inclusion criteria and/or declined to participate (n = 34) were excluded from the study. Patients were divided into two groups. Four patients from Group 1 and four patients from Group 2 were lost to follow‐up. Group 1 (n = 30) received sevoflurane, and Group 2 (n = 30) received desflurane during anesthesia. We compared the results by performing the pre‐op and post‐op Connecticut Chemosensory Clinical Research Center Olfactory test. Results: Thirty‐three patients (55%) were male and 27 (45%) were female. The mean age was 48.18 ± 13.88 years (range: 19‐70 years). Preoperative and postoperative olfactory functions did not show a significant difference within the groups postoperatively (p > 0.05). Preoperative and postoperative olfactory memory showed a significant decrease 3 hours after the surgery (p < 0.05). Conclusions: Olfactory functions and memory were not affected by desflurane in the early postoperative period. Although sevoflurane did not affect olfactory functions, it had a temporary negative effect on olfactory memory in the early postoperative period.