Current perspectives on drug release studies from polymeric nanoparticles
Organic Materials as Smart Nanocarriers for Drug Delivery, Elsevier, ss.101-145, 2018
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2018
- Doi Numarası: 10.1016/b978-0-12-813663-8.00003-8
- Yayınevi: Elsevier
- Sayfa Sayıları: ss.101-145
- Anahtar Kelimeler: Dissolution, Drug release, In vitro, Liquid chromatography, Pharmaceuticals, Polymeric nanoparticle
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In vitro drug release testing is an important tool in drug development; it facilitates comparing the performance of different formulations and enables choosing the most suitable formulation. Polymeric nanoparticles (NPs), such as poly(lactic-co-glycolic acid), chitosan, poly(methyl methacrylate), etc., are colloidal systems that have been the focus of extensive investigations. Biomedical applications of polymeric NPs have been considered in numerous areas of medicine, due to their ability to control drug release and distribution, as well as their biodegradability. Especially for poorly water-soluble drug incorporated NPs, drug release study design affects release time and sink conditions. For drug-loaded polymeric NPs, pharmacopoeial dissolution apparatuses are not commonly used, due to unsuitability of both the paddle and basket apparatus. Nonuniform hydrodynamics and fluctuations in the dissolution rate measurements limit dissolution tests. Due to lack of an official test, some methods using orbital shaker, magnetic stirrer, and flow-through cell, etc., with or without dialysis bag, are offered. In this chapter, commonly used methods for polymeric NP drug release studies are explained from the view point of NP characteristics, dissolution medium, apparatus, and biomedical applications.