Association between middle cerebral artery doppler flow parameters and intraventricular hemorrhage in preterm infants
Neuroendocrinology Letters, cilt.46, sa.4, ss.205-215, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 4
- Basım Tarihi: 2025
- Dergi Adı: Neuroendocrinology Letters
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.205-215
- Anahtar Kelimeler: Intraventricular hemorrhage, middle cerebral artery, Doppler ultrasound, cerebral blood flow, preterm infants
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
PURPOSE: To evaluate whether middle cerebral artery (MCA) Doppler flow parameters measured in the first week of life are associated with intraventricular hemorrhage (IVH) in preterm infants. METHODS: A prospective cohort study was conducted in a level 4A neonatal intensive care unit (NICU) at Adana City Training and Research Hospital between March 2022 and April 2023. Preterm infants born weighing ≤1250 g and ≥500 g were included. MCA flow parameters, including peak systolic velocity (PSV), peak diastolic velocity (PDV), pulsatility index (PI), resistivity index (RI) and time-averaged maximum velocity (TAMAX) were measured via transfontanel Doppler ultrasonography within the first five days of life every day. The associa tion between MCA Doppler parameters and IVH development was analyzed. RESULTS: Ninety-two preterm infants were included. IVH was detected in 34.7% (n = 32). Infants with IVH had lower gestational age and birth weight. Logistic regression revealed that lower birth weight, the presence of PDA, and early-onset sepsis increased IVH risk. Both increased and decreased MCA Doppler param eters (PSV, PDV, PI and TAMAX) preceded IVH. CONCLUSION: MCA Doppler flow fluctuations were associated with IVH in preterm infants. These associations warrant further investigation to determine whether MCA Doppler measurements can prospectively identify infants at risk for IVH.