The effect of oral isotretinoin therapy on meibomian gland morphology and dry eye tests
Journal of Dermatological Treatment, cilt.33, sa.2, ss.762-768, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/09546634.2020.1774041
- Dergi Adı: Journal of Dermatological Treatment
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.762-768
- Anahtar Kelimeler: Acne vulgaris, dry eye disease, isotretinoin, meibography, meibomian gland dysfunction
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: The aim of study was to evaluate the effects of oral isotretinoin on meibomian gland (MG) morphology detected with non-contact meibography and to investigate its relation with clinical dry eye tests. Methods: Forty-five acne patients treated with isotretinoin underwent a full ophthalmological examination at baseline and in the fourth month as follows: ocular surface disease index (OSDI) questionnaire, assessments of tear film break-up time (TFBUT), corneal fluorescein staining, Schirmer test, meibum expression, and lid margin abnormalities. Non-contact meibography imaging and noninvasive tear break up time (NI-BUT) assessments were also performed. The changes in MGs were scored (meibography score) as grade 0, no change; grade 1, mild; grade 2, moderate; and grade 3, marked. Results: There was a statistically significant change in OSDI, corneal fluorescein staining, lid margin abnormality, and meibum expression score during the treatment compared to baseline values (p <.001, p =.02, p <.001, and p <.001, respectively). All meibography scores showed a positive correlation with the lid margin abnormality and meibum expression score but did not correlate with the TFBUT, NI-BUT, Schirmer test, or the corneal fluorescein staining score. Conclusion: The morphologic analysis using non-contact meibography is a useful method for assessing isotretinoin-related changes in MGs.