In vivo gamma scintigraphic evaluation and determination of a gastro-resistant etodolac tablet in humans
Combinatorial Chemistry and High Throughput Screening, cilt.13, sa.6, ss.490-496, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 6
- Basım Tarihi: 2010
- Doi Numarası: 10.2174/138620710791515833
- Dergi Adı: Combinatorial Chemistry and High Throughput Screening
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.490-496
- Anahtar Kelimeler: Gamma scintigraphy, bioavailability, etodolac, gastro-resistant tablets, gastrointestinal transit
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
A gastro-resistant (enteric coated) etodolac tablet dosage form, was evaluated by using in vitro and in vivo methods. In vitro drug release studies have shown that enteric coated tablet dosage form protects the drug from being released under conditions mimicking stomach to small intestine transit. The gastro-intestinal transit of radiolabeled 300 mg enteric coated etodolac tablets in six healthy, fed and fasted state voluntrees was monitored using external gamma camera. Dosage form position was reported at several time intervals. Etodolac serum concentrations were determined from serum samples drawn over 420 min following dosing. Differences in gastro-intestinal transit between fed and fasted volunteers had little effect on etodolac bioavailability. AUC, Tmax and C max values were calculated for both types of studies. © 2010 Bentham Science Publishers Ltd.