Complete blood count alterations after six months of continuous positive airway pressure treatment in patients with severe obstructive sleep apnea
Journal of Clinical Sleep Medicine, cilt.10, sa.8, ss.873-878, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 8
- Basım Tarihi: 2014
- Doi Numarası: 10.5664/jcsm.3958
- Dergi Adı: Journal of Clinical Sleep Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.873-878
- Anahtar Kelimeler: continuous positive airway pressure, obstructive sleep apnea, mean platelet volume, platelet distribution width, red cell distribution width
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Study Objectives: The cardiovascular complications caused by obstructive sleep apnea (OSA) decrease after continuous positive airway pressure treatment (CPAP). Mean platelet volume (MPV), platelet distribution width (PDW), and red cell distribution width (RDW) are newly recognized tools for assessing cardiovascular risk. Methods: From a selection of patients with symptoms of nocturnal snoring and/or excessive daytime sleepiness, 36 males with an apnea-hypopnea index (AHI) > 30/h and 22 age-matched normal male controls with AHI < 5/h were included. Patients with OSA underwent another night of CPAP titration, and 11 patients were excluded at the 6-month evaluation due to poor compliance with the home CPAP therapy. Complete blood count parameters of compliant patients and the control group were evaluated. Results: Compared to controls, MPV values were signifi cantly higher (p = 0.025) in OSA patients, but no signifi cant differences in PDW or RDW were found (p > 0.05). Six months of CPAP therapy resulted in signifi cantly lower MPV values but increased values of PDW and RDW in patients with severe OSA (p = 0.001, p = 0.007, p = 0.001, respectively). Conclusion: Our data suggest that complete blood count parameters in OSA patients such as MPV, PDW and RDW change signifi cantly after CPAP therapy.