Radiotherapy in Adjuvant Therapy in High-intermediate Risk and High Risk Endometrial Cancer: A Review Article Orta-yüksek Risk ve Yüksek Risk Endometrium Kanserinde Adjuvan Tedavide Radyoterapi: Derleme Makalesi
Anatolian Journal of General Medical Research, cilt.33, sa.1, ss.7-11, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 33 Sayı: 1
- Basım Tarihi: 2023
- Doi Numarası: 10.4274/terh.galenos.2021.24650
- Dergi Adı: Anatolian Journal of General Medical Research
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.7-11
- Anahtar Kelimeler: adjuvant therapy, Endometrial cancer, high risk, high-intermediate risk, radiotherapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In uterine cancers, except grade (G), depth of myometrial invasion, lymph node (LN) involvement; histology, presence of lymphovascular invasion (LVI), tumor size, age, and stage are among other well-defined clinico pathological prognostic factors. According to the presence of these factors, the patients were classified as low-intermediate and high-risk groups. 80-85% of uterine cancer is an early stage, and 15-20% of patients constitute the advanced high-risk group. In adjuvant therapies, to be able to choose between increasing progression-free survival and inducing toxicity, perhaps identifying stage III-IV patients with higher relapse potential and giving them combined therapies may be an option. Poor risk factors such as positive paraaortic/pelvic LN metastasis, postoperative gross residue, multiple extrauterine spread, high G, lymphovascular invasion, peritoneal spread, papillary/clear cell histology, and advanced age can help us in making more aggressive treatment decisions.