Evaluation of neutrophil to lymphocyte ratio and mean platelet volume in attack and attack-free periods in familial mediterranean fever patients Ailesel akdeniz ateşi tanılı hastalarda atak ve atak dışı dönemlerdeki nötrofil-lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi
Turkiye Klinikleri Journal of Medical Sciences, cilt.39, sa.2, ss.179-186, 2019 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.5336/medsci.2018-62619
- Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.179-186
- Anahtar Kelimeler: Familial mediterranean fever, Inflammation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To determine the neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) values in the attack and attack-free periods of familial Mediterranean fever (FMF) patients and to investigate their association with acute phase reactants and MEFV gene mutations. Material and Methods: 97 patients with FMF and 60 healthy controls were included in this study. Demographic characteristics and laboratory data were retrospectively recorded. Results: NLR values were significantly higher in the FMF patients at the time of attack than in the attack-free patients and control groups (4.67±3.66 vs 1.83±0.64, 4.67±3.66 vs 2.03±0.66, respectively). MPV levels were significantly lower in the attack period compared with attack-free period and there was no difference between the attack period and the control group (8.53±1.12 vs 8.89±1.28, 8.53±1.12 vs 8.74±0.89, respectively). There was a significant correlation between NLR and C-reactive protein (CRP) during the attack period. The NLR value in the attack-free period was significantly higher in the cases with M694V homozygote mutation than in the cases without this mutation (2.16±0.79 vs 1.76±0.57). Conclusion: Increase in NLR levels and decrease in MPV values can be used as acute phase reactants in the attack periods of patients with FMF. Elevation of NLR levels in attack-free period can be considered as a subclinical inflammatory marker especially in cases with M694V homozygous mutation and allows us to be more alert to the development of amyloidosis.