Mean platelet volume increase after tamoxifen, but not after anastrazole in adjuvant therapy of breast cancer
Medical Oncology, cilt.27, sa.2, ss.199-202, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 2
- Basım Tarihi: 2010
- Doi Numarası: 10.1007/s12032-009-9191-2
- Dergi Adı: Medical Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.199-202
- Anahtar Kelimeler: Mean platelet volume, Anastrazole, Tamoxifen, Platelets
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Aim: To investigate differences of platelet indices in breast cancer patients after tamoxifen (tmx) and anastrazole adjuvant treatment. Methods: In this retrospective study, 46 postmenopausal women (20 with tmx and 26 with anastrazole) with breast cancer who received adjuvant hormone therapy were enrolled. The biochemical and complete blood count (CBC) parameters were documented before hormone treatment start and after 1 year. Results: The lymphocyte count was higher after tmx use, but not anastrazole. Total white blood cells were increased both after 1-year tmx and anastrazole using. Mean platelet volume (MPV) increased after tmx use (8.2 ± 0.94- 8.97 ± 0.97; P: 0.041), while it was not different after anastrazole use (7.96 ± 1.08-7.89 ± 0.99; P: 0.585). Other platelet parameters did not alter with tmx or anastrazole treatment. Conclusion: We found increased MPV after tmx treatment, but did not after anastrazole treatment. The advanced studies which explore biological significance of high MPV in breast cancer patients used endocrine therapy, should be established. ©2009 Humana Press Inc.