Impact of the 1,2,3-triazole compound derived from salicylaldehyde on localized and systemic organ injury in an experimental superior mesenteric artery ischemia/ reperfusion model Deneysel superior mezenterik arter iskemi/reperfüzyon modelinde salisilaldehitten türetilmiş 1,2,3 triazol bileşiğinin lokalize ve sistemik organ hasarı üzerindeki etkisi
Ulusal Travma ve Acil Cerrahi Dergisi, cilt.32, sa.2, ss.109-117, 2026 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.14744/tjtes.2025.26900
- Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.109-117
- Anahtar Kelimeler: Ischemia/reperfusion, triazole, liver, small intestine, superior mesenteric artery.
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND: Despite several studies indicating the efficacy of different molecules in preventing ischemia/reperfusion (I/R) damage, the most effective treatment remains unknown. METHODS: This study included 28 male Sprague rats, which were randomly assigned to four equal groups, with seven rats in each group: Group S (Sham), Group C (Control), Group E (Ethanol), and Group T (Triazole). The superior mesenteric arteries of rats in all groups except Group S were exposed and closed with a vascular clamp, and ischemia was induced for one hour. Oxidative stress parameters, ischemia markers, and biochemical tests indicating organ function were examined. RESULTS: The mean total antioxidant status (TAS) value of Group T was significantly higher than those of Groups C and E, while being significantly lower than that of Group S (p=0.001). The mean total oxidant status (TOS) value of Group T was significantly lower than those of Groups C and E and significantly higher than that of Group S (p<0.001). Although the mean oxidative stress index (OSI) value of Group T was markedly lower than those of Groups C and E, no statistically significant difference was observed compared to Group S (p=0.002, p<0.001, and p=0.721, respectively). The mean ischemia-modified albumin (IMA) value of Group T was significantly lower than those of Groups C and E and significantly higher than that of Group S (p<0.001). The mean malondialdehyde (MDA) value of Group T was significantly lower than those of Groups C and E and significantly higher than that of Group S (p<0.001). CONCLUSION: This study represents the first investigation into the effect of a 1,2,3-triazole compound derived from salicylaldehyde on ischemia/reperfusion injury. The findings provide strong evidence that the 1,2,3-triazole compound significantly enhances the prevention or treatment of experimental I/R injury. We conclude that this triazole derivative may represent a viable therapeutic option for the treatment and prevention of I/R injury, supported by further experimental and clinical research. The triazole is expected to exhibit enhanced protective properties, particularly when solubilized using alternative methods.