Genes Encoding Ion Channels in Neurotherapeutics: Opportunities and Challenges
Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities, Springer Nature, ss.201-217, 2024
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2024
- Doi Numarası: 10.1007/978-981-99-6807-7_9
- Yayınevi: Springer Nature
- Sayfa Sayıları: ss.201-217
- Anahtar Kelimeler: Gene therapy, Ion channels, K+ channels, Neurotherapeutic
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Neurotherapy measures and regulates the electrical signals produced by the neurons of the brain. The variation of the electrical activity in the measurement performed by electroencephalography determines the coefficient of application of neurotherapy. Serious changes in electrical activity lead to the onset of diseases including epilepsy, Alzheimer’s disease, Parkinson’s disease, and multiple scle-rosis. Recent devices producing electric current or magnetic field are used in neurotherapy, as well as molecules that regulate the chemical processes of cells as neurotherapeutics. The treatment of genes encoding ion channels is a great chance for the healing effect of devices on much larger biosystems. However, the type of mutations in the genes encoding these proteins, which are responsible for the transmission of information and direct the ionic movements of neurons, deter-mine the degree of improvement of the related neurological diseases with neurotherapeutics. Mutations can cause changes in the structure that conducts the opening and closing of the ion channel, changing the number of ion transitions. In this case, the implementation of a treatment is essential while there are still limitations to the use of neurotherapeutics. In this chapter, studies on the amelioration of mutations in genes encoding ion channels with neurotherapeutics will be explained. In this narrative, opportunities and challeng-ing conditions will be prioritized.