From Plants to Skin: The Multifaceted Benefits of Rosmarinic Acid
Rosmarinic Acid: Phytochemistry, Biosynthesis, and Therapeutic Applications, NOVA Publications , ss.85-101, 2026
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2026
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.85-101
- Anahtar Kelimeler: anti-inflammatory, anticancer, antioxidant, rosmarinic acid, skin diseases
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, has a variety of pharmacological activities. RA, a phenolic compound, is most found in the Boraginaceae and Lamiaceae families. It possesses antiviral, antibacterial, analgesic, anti-inflammatory, anticancer, and antioxidant activities. It can be administered to the human body in many ways, such as topically, pulmonarily, intranasally, and intravenously. It exhibits anti-inflammatory effects through the inhibition of lipoxygenase, cyclooxygenase, the complement cascade, and pro-inflammatory mediators. Due to its antioxidant and anti-inflammatory effects, RA has been studied in recent years for its effects on the skin. Studies have shown that it may contribute to the inhibition of local and systemic inflammatory reactions in the skin, effectively reducing skin lesions and levels of inflammatory cytokines and chemokines. It has also been reported to show cytoprotective effects against ultraviolet (UV) B radiation by regulating cellular antioxidant systems in keratinocytes and improving oxidative damage. Topically applied creams have been reported to significantly improve skin barrier functions by reducing skin surface pH and transepidermal water loss and increasing skin hydration. Due to RA’s biological activities and low toxicity, it is thought that it may help protect or improve skin barrier functions and skin diseases, reducing the causes and effects of cancer. Due to this knowledge, this chapter aims to focus on studies investigating the skin effects and toxicity of RA.