Evaluation of fluoxetine induced brain-derived neurotrophic factor on facial nerve healing (experimental study)
Journal of International Advanced Otology, cilt.8, sa.2, ss.179-186, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 2
- Basım Tarihi: 2012
- Dergi Adı: Journal of International Advanced Otology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.179-186
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Our aim is to evaluate the effect of fluoxetine treatment on serum Brain Derived Neurotrophic Factor levels as well as facial nerve healing by an experimental facial nerve crush injury in rat model. Materials and Methods: 38 rats were allocated and rats were divided into five groups (Group A, B, A1, B1, C). Temporary facial nerve crush injury was performed in Group A, B, A1 and B1. Groups A1 and B1 were not treated with any drug. Fluoxetin, at a dose of 1 mg/ kg/ day, was injected intraperitoneally for 7 days in Group A, and for 28 days in Group B. Group C did not have any injury or treatment. Electromyography evaluation was performed at 7th day in Group A and A1, and at 28th day in Group B and B1. Brain Derived Neurotrophic Factor levels were measured from serum samples. Results: There were no statistically significant increase of Brain Derived Neurotrophic Factor levels after fluoxetine treatment in Group A and B. Fluoxetine treatment did not affect the latency period on 7th day. On 28th day, it shortened the latency, though not significantly. Amplitude values revealed significant improvement between 7th day (Group A1 and A) and 28th day (Group B1 and B). Conclusion: No significant effect of fluoxetine has been shown on serum Brain Derived Neurotrophic Factor levels or on facial nerve recovery following facial nerve injury. Further studies should be performed to ascertain the effective dose of Fluoxetine and proper application method. © 2005 The Mediterranean Society of Otology and Audiology.