Preoperative neutrophil-to-C-reactive protein ratio as a predictor of post-operative complications of pancreas cancer Relación preoperatoria de neutrófilos a proteína C reactiva como predictor de complicaciones posoperatorias del cáncer de pancreas
Cirugia y Cirujanos (English Edition), cilt.92, sa.4, ss.481-486, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 92 Sayı: 4
- Basım Tarihi: 2024
- Doi Numarası: 10.24875/ciru.22000544
- Dergi Adı: Cirugia y Cirujanos (English Edition)
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.481-486
- Anahtar Kelimeler: Pancreas cancer, Postoperative complication, Neutrophil-to-C-reactive protein ratio
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: We would like to investigate the prognostic utility of the previously described factors and offer a new parameter called neutrophil-to-C-reactive protein ratio (NCR) as a predictor of post-operative complications of pancreas cancer. Methods: 92 patients underwent pancreaticoduodenectomy for the pancreatic head tumor were enrolled in this study. Receiver operating curve analysis was performed to detect the cutoff values, and logistic regression analyses were performed to identify the independent risk factors of complications. Results: In univariate analysis, complications were observed in lymphocyte-to-C-reactive protein ratio levels below 0.06 (Odds Ratio [OR]: 3.92, 95% confidence interval [CI] = 1.08-14.21, p = 0.037). In multivariate analysis, albumin < 3.6 (OR: 3.25, 95% CI: 1.16-9.06, p = 0.024) and NCR < 0.28 (OR: 2.81, 95 % CI: 1.07-7.63, p = 0.042) were the independent and significant predictors of the overall survival. Discussion: Quantification of preoperative NCR and albumin may help surgeons to settle an effective perioperative management, take extra caution, and be aware of post-operative complications of pancreatic cancer patients.