Inflammatory Markers in Adolescents with Polycystic Ovary Syndrome: Association with Androgen Levels
Journal of Pediatric Research, cilt.13, sa.1, ss.65-71, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/jpr.galenos.2026.77603
- Dergi Adı: Journal of Pediatric Research
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.65-71
- Anahtar Kelimeler: Polycystic ovary syndrome, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte, systemic immune-inflammation index
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: Polycystic ovary syndrome (PCOS) is increasingly recognized as a systemic disorder associated with metabolic abnormalities and chronic inflammation. In this study, we aimed to investigate the relationship between androgen levels and inflammatory markers in adolescents with PCOS. Materials and Methods: Eighty-nine patients with PCOS were analyzed retrospectively. Inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), were assessed. Androgen levels and metabolic parameters were also evaluated. Results: The inflammatory markers were not significantly associated with androgen levels or hyperandrogenism. No significant differences in NLR, PLR, or SII were observed between adolescents with and those without hyperandrogenism or between patients with obesity and those without obesity (all p>0.05). Body mass index (BMI) and BMI-standard deviation scores were not correlated with inflammatory markers. In contrast, homeostasis model assessment of insulin resistance showed a weak but statistically significant positive correlation with SII. Conclusion: Our findings demonstrate that inflammatory markers, including NLR, PLR, and SII, were not significantly associated with androgen levels. Furthermore, these markers did not differ according to the presence of obesity or hyperandrogenism.