Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue
Polish Journal of Pharmacology, cilt.54, sa.3, ss.255-259, 2002 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 3
- Basım Tarihi: 2002
- Dergi Adı: Polish Journal of Pharmacology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.255-259
- Anahtar Kelimeler: Nimesulide, Ranitidine, Rat, Ulcer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study, we examined the effect of nimesulide and ranitidine on the indomethacin- and ibuprofen-induced ulcer. In addition, we investigated whether there was a direct chemical interaction of nimesulide and ranitidine with indomethacin, and also whether nimesulide and ranitidine neutralized the gastric acid in vitro. Our studies showed that nimesulide (100, 300, 500 mg/kg) prevented the indomethacin-induced gastric ulcers completely. Ranitidine at a dose of 150 mg/kg reduced the mean ulcer area to 2.5 ± 0.76 mm2 in the indomethacin-treated and to 2.0 ± 0.81 mm2 in ibuprofen-treated rats. The mean ulcer areas in rats given only indomethacin and only ibuprofen were 20.3 ± 1.58 mm2 and 9.5 ± 1.43 mm2 respectively. There were no chemical reactions between nimesulide and indomethacin or ranitidine and indomethacin in vitro. Nimesulide and ranitidine did not neutralize the gastric acid in vitro.